靶点/蛋白:Rabbit anti-Human GPR15 antibody recognizes Human G-protein coupled receptor 15 (GPR15) also known as Brother of Bonzo (BOB), a ~41 kDa multi-pass membrane protein. Human immunodeficiency virus (HIV) and related viruses require coreceptors to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four additional human molecules GPR15, STRL33, GPR1 and V28 have now been identified as HIV coreceptors. The genes encoding human and monkey GPR15/BOB have been cloned and research has demonstrated that his novel G protein-coupled receptor serves as co-receptor for simian immunodeficiency virus (SIV), and for strains of HIV-2 and M-tropic HIV-1.
来源:Rabbit
参考文献:1. Heiber M., et al (1996) A novel human gene encoding a G-protein-coupled receptor (GPR15) is located on chromosome 3.Genomics 32:462-5.2. Deng H.K., et al (1997) Expression cloning of new receptors used by simian and human immunodeficiency viruses.Nature 388:296-300.3. Farzan M., et al (1997) Two orphan seven-transmembrane segment receptors which are expressed in CD4-positive cells support simian immunodeficiency virus infection.J. Exp. Med. 186:405-11.
特异性:Human
别名:G-protein coupled receptor 15, Brother of Bonzo, BoB, GPR15
简单描述:Rabbit Polyclonal Anti-Human GPR15 (N-Terminal) Antibody . Validated for use in WB.