产品概述:Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity and plays a role in various processes in adults such as regulation of blood pressure, heart contractility, and heart failure. Also plays a key role in early development such as gastrulation and heart morphogenesis by acting as a receptor for APELA hormone. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia.
靶点/蛋白:Human Apelin Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
来源:Rabbit
参考文献:O'Dowd B.F.,et al.Gene 136:355-360(1993).Eggerickx D.,et al.Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases.
简单描述:Rabbit Polyclonal APLNR/ Apelin Receptor / APJ Antibody (Extracellular Domain). Validated for use in IHC-P.
详情:FunctionReceptor for apelin coupled to G proteins that inhibit adenylate cyclase activity and plays a role in various processes in adults such as regulation of blood pressure, heart contractility, and heart failure. Also plays a key role in early development such as gastrulation and heart morphogenesis by acting as a receptor for APELA hormone. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia.Cellular_LocationCell membrane; Multi-pass membrane protein.Tissue_LocationWidely expressed in the brain, in glial cells, astrocytes and neuronal subpopulations, as well as in the spleen, thymus, ovary, small intestine and colon