靶点/蛋白:ABD10974 detects human peroxisome proliferator-activated receptor ? (PPARG), a member of the nuclear hormone receptor subfamily of transcription factors. Upon activation, PPARG forms heterodimers with retinoid X receptors (RXRs), and functions to regulate transcription of specific gene sequences. PPARG is principally involved in the cellular assimilation of lipids, with key roles in adipocyte differentiation and adipogenesis. Two alternatively spliced isoforms of PPARG exist, termed PPARG1 and PPARG2, which are identical except for an additional 30 amino acids at the N-terminus of PPARG2. This results in a predominant adipocyte localisation for PPARG2, whilst PPARG1 is ubiquitously expressed. PPARG has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer.
来源:Rabbit
参考文献:1. Lazar, M.A. (2005) PPAR gamma, 10 years later. Biochimie. 87: 9-13.2. Lehrke, M. and Lazar, M.A. (2005) The many faces of PPARgamma. Cell. 123: 993-999.
特异性:Human
别名:Peroxisome proliferator-activated receptor gamma, PPAR-gamma, Nuclear receptor subfamily 1 group C member 3, PPARG, NR1C3
简单描述:Rabbit Polyclonal Anti-PPAR gamma Antibody . Validated for use in E.