靶点/蛋白:ABD11008 detects an epitope within the N-terminal of the serotonin (5-hydroxytryptamine, 5-HT) receptor 5-HT7, which belongs to the G-protein coupled receptor superfamily. Serotonin is a neurotransmitter and vasoactive amine which is thought to play a role in various cognitive and behavioural functions including pain, appetite, mood and sleep. Signalling through 5-HT7 has several effects, including regulation of the circadian rhythm and mediation of smooth-muscle relaxation in the vasculature and gastrointestinal tract. Signalling though 5-HT7 has also been shown to contribute to early T-cell activation. 5-HT7 has been implicated in depression, autism, and other neuropsychiatric disorders.
来源:Rabbit
参考文献:1. León-Ponte M, et al. (2007) Serotonin provides an accessory signal to enhance T-cell activation by signaling through the 5-HT7 receptor.Blood. 109: 3139-3146. 2. Soll, C. et al. (2012) Expression of serotonin receptors in human hepatocellular cancer.Clin Cancer Res. 18: 5902-10.