产品概述:Angiotensin II is a potent vasopressor hormone and aprimary regulator of aldosterone secretion. It is an importanteffector controlling blood pressure and volume in thecardiovascular system. It acts through at least two types ofreceptors. This gene encodes the type 1 receptor which is thoughtto mediate the major cardiovascular effects of angiotensin II. Thisgene may play a role in the generation of reperfusion arrhythmiasfollowing restoration of blood flow to ischemic or infarctedmyocardium. It was previously thought that a related gene, denotedas AGTR1B, existed; however, it is now believed that there is onlyone type 1 receptor gene in humans. At least five transcriptvariants have been described for this gene. Additional variantshave been described but their full-length nature has not beendetermined. The entire coding sequence is contained in the terminalexon and is present in all transcript variants. [provided byRefSeq].
靶点/蛋白:This AGTR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 211-240 amino acids from the Central region of human AGTR1.
来源:Rabbit
存储溶液:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
参考文献:Xu, M., et al. Atherosclerosis 213(1):191-199(2010)Niu, W., et al. Hypertens. Res. 33(11):1137-1143(2010)Procopciuc, L.M., et al. Eur. J. Intern. Med. 21(5):414-418(2010)Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :Schuur, M., et al. J. Neurol. Neurosurg. Psychiatr. (2010) In press :
特异性:Human
别名:Type-1 angiotensin II receptor, AT1AR, AT1BR, Angiotensin II type-1 receptor, AT1, AGTR1, AGTR1A, AGTR1B, AT2R1, AT2R1B
应用:IF~~1:25WB~~1:1000IHC-P~~1:10~50FC~~1:10~50
简单描述:Rabbit Polyclonal AGTR1 Antibody (Center). Validated for use in IF, FC, WB, IHC-P, E.
详情:FunctionReceptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system.Cellular_LocationCell membrane; Multi-pass membrane protein.Tissue_LocationLiver, lung, adrenal and adrenocortical adenomas