产品概述:BAG4 is a member of theBAG1-related protein family. BAG1 is an anti-apoptotic protein thatfunctions through interactions with a variety of cell apoptosis andgrowth related proteins including BCL-2, Raf-protein kinase,steroid hormone receptors, growth factor receptors and members ofthe heat shock protein 70 kDa family. This protein contains a BAGdomain near the C-terminus, which could bind and inhibit thechaperone activity of Hsc70/Hsp70. This protein was found to beassociated with the death domain of tumor necrosis factor receptortype 1 (TNF-R1) and death receptor-3 (DR3), and thereby negativelyregulates downstream cell death signaling. The regulatory role ofthis protein in cell death was demonstrated in epithelial cellswhich undergo apoptosis while integrin mediated matrix contacts arelost.
靶点/蛋白:This BAG4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 381-409 amino acids from the C-terminal region of human BAG4.
来源:Rabbit
存储溶液:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
参考文献:Bailey, S.D., et al. Diabetes Care (2010) In press :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Tao, H.F., et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi 15(3):501-505(2007)Riley, B.M., et al. Am. J. Med. Genet. A 143A (8), 846-852 (2007) :Yang, Z.Q., et al. Cancer Res. 66(24):11632-11643(2006)
特异性:Human
别名:BAG family molecular chaperone regulator 4, BAG-4, Bcl-2-associated athanogene 4, Silencer of death domains, BAG4, SODD
应用:WB~~1:1000
简单描述:Rabbit Polyclonal BAG4 Antibody (C-term). Validated for use in WB, E.
详情:FunctionInhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PARK2 translocation to damaged mitochondria.Cellular_LocationCytoplasm.Tissue_LocationUbiquitous.