产品概述:The protein encoded by this gene is a member of theankyrin repeat and SOCS box-containing (ASB) family of proteins.They contain ankyrin repeat sequence and SOCS box domain. The SOCSbox serves to couple suppressor of cytokine signalling (SOCS)proteins and their binding partners with the elongin B and Ccomplex, possibly targeting them for degradation. This gene isinduced by all-trans retinoic acid. In myeloid leukemia cells, theexpression of this encoded protein has been shown to induce growthinhibition and chromatin condensation. Multiple alternativelyspliced transcript variants have been described for this gene buttheir full length sequences are not known.
靶点/蛋白:This ASB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-86 amino acids from the N-terminal region of human ASB2.
来源:Rabbit
存储溶液:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
参考文献:Heuze, M.L., et al. Blood 112(13):5130-5140(2008)Kohroki, J., et al. FEBS Lett. 579(30):6796-6802(2005)Heuze, M.L., et al. J. Biol. Chem. 280(7):5468-5474(2005)Colland, F., et al. Genome Res. 14(7):1324-1332(2004)Namciu, S.J., et al. Mamm. Genome 15(3):162-178(2004)
特异性:Human
别名:Ankyrin repeat and SOCS box protein 2, ASB-2, ASB2
应用:WB~~1:1000
简单描述:Rabbit Polyclonal ASB2 Antibody (N-term). Validated for use in WB, E.
详情:FunctionSubstrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.