靶点/蛋白:Rabbit anti-RIP3 antibody recognizes mouse serine-threonine kinase receptor-interacting protein 3 (RIP3). RIP3 is related to RIP and RIP2 but does not posses a death domain or CARD motif at its C-terminus. RIP3 activates NF-Kappa B and potently induces apoptosis.RIP3 is expressed in a range of tissues including the spleen, liver, testis, heart, brain and lung.
来源:Rabbit
参考文献:1. Günther, C. et al. (2011) Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis.Nature. 477: 335-9. 2. Meng L et al. (2015) RIP3-mediated necrotic cell death accelerates systematic inflammation and mortality.Proc Natl Acad Sci U S A. pii: 201514730. 3. Huang, S.C. et al. (2014) Tumor necrosis factor suppresses NR5A2 activity and intestinal glucocorticoid synthesis to sustain chronic colitis.Sci Signal. 7 (314): ra20. 4. Mizumura, K. et al. (2014) Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD.J Clin Invest. 124 (9): 3987-4003. 5. Feng, S. et al. (2007) Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain.Cell Signal. 19 (10): 2056-67.1. Yu, P.W., et al (1999) Identification of RIP3, a RIP-like kinase that activates apoptosis and NF-κB. Curr. Biol. 9:539-422. Sun, X., et al (1999) RIP3, a novel apoptosis-inducing kinase. J Biol Chem. 274:16871-5.3. Pazdernik, N.J., et al (1999) Mouse receptor interacting protein 3 does not contain a caspase-recruiting or a death domain but induces apoptosis and activates NF-κB. Mol Cell Bio.19:6500-8
特异性:Mouse
别名:Receptor-interacting serine/threonine-protein kinase 3, 2.7.11.1, RIP-like protein kinase 3, Receptor-interacting protein 3, RIP-3, mRIP3, Ripk3, Rip3
简单描述:Rabbit Polyclonal Anti-RIP3 Antibody . Validated for use in WB, IHC-P.