产品概述:Expression of this gene is induced byhexamethylene-bis-acetamide in vascular smooth muscle cells. Thisgene has no introns.
靶点/蛋白:This HEXIM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-46 amino acids from the N-terminal region of human HEXIM1.
来源:Rabbit
存储溶液:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
参考文献:Dow, E.C., et al. J. Cell. Physiol. 224(1):84-93(2010)Ogba, N., et al. Oncogene 29(25):3639-3649(2010)Schonichen, A., et al. Biochemistry 49(14):3083-3091(2010)Czudnochowski, N., et al. J. Mol. Biol. 395(1):28-41(2010)Krueger, B.J., et al. PLoS ONE 5 (8), E12335 (2010) :
特异性:Human, Mouse
别名:Protein HEXIM1, Cardiac lineage protein 1, Estrogen down-regulated gene 1 protein, Hexamethylene bis-acetamide-inducible protein 1, Menage a quatre protein 1, HEXIM1, CLP1, EDG1, HIS1, MAQ1
应用:WB~~1:1000IHC-P~~1:10~50
简单描述:Rabbit Polyclonal HEXIM1 Antibody (N-term). Validated for use in WB, IHC-P, E.
详情:FunctionTranscriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity.Cellular_LocationNucleus. Cytoplasm. Note=Binds alpha- importin and is mostly nuclearTissue_LocationUbiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed Expressed in endocrine tissues.