产品概述:Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity).
靶点/蛋白:The peptide sequence of this antibody is corresponding to amino acids of human 1-50aa. This antibody is predicted to recognize mouse and rat TLE4 protein because of synthesized peptide amino acid 100% homology with mouse and rattus TLE4 protein.
简单描述:Rabbit Polyclonal GRG4 / TLE4 Antibody (N-Terminus). Validated for use in WB, IHC-P, E.
详情:FunctionTranscriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity).Cellular_LocationNucleus.Tissue_LocationIn all tissues examined, mostly in brain, and muscle