靶点/蛋白:This mouse Shh antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 58-91 amino acids from the N-terminal region of mouse Shh.
来源:Rabbit
存储溶液:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
特异性:Human, Mouse, Rat
应用:WB~~1:2000IF~~1:25IHC-P~~1:25FC~~1:25
简单描述:Rabbit polyclonal (Mouse) Shh Antibody (N-term). Validated for use in WB, IF, IHC-P, FC, E.
详情:FunctionIntercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior- posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction. Activates the transcription of target genes by interacting with its receptor PTCH1 to prevent normal inhibition by PTCH1 on the constitutive signaling activity of SMO.Cellular_LocationSonic hedgehog protein C-product: Secreted, extracellular space. Note=The C-terminal peptide diffuses from the cellTissue_LocationExpressed in a number of embryonic tissues including the notochord, ventral neural tube, floor plate, lung bud, zone of polarizing activity and posterior distal mesenchyme of limbs. In the adult, expressed in lung and neural retina