产品概述:RYK is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. A nine nucleotide insertion in some transcripts results in the SLG variant. It is not established whether this is a product of alternative splicing or a second gene, since evidence for a second gene or pseudogene on chromosome 17 exists.
靶点/蛋白:This RYK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 383-410 amino acids from the Central region of human RYK.
来源:Rabbit
存储溶液:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
参考文献:Trivier, E., et al., J. Biol. Chem. 277(25):23037-23043 (2002).Katso, R.M., et al., Mol. Cell. Biol. 19(9):6427-6440 (1999).Wang, X.C., et al., Mol. Med. 2(2):189-203 (1996).Tamagnone, L., et al., Oncogene 8(7):2009-2014 (1993).Stacker, S.A., et al., Oncogene 8(5):1347-1356 (1993).
特异性:Human
别名:Tyrosine-protein kinase RYK, RYK, JTK5A
应用:WB~~1:1000
简单描述:Rabbit Polyclonal RYK Antibody (Center C397). Validated for use in WB, E.
详情:FunctionMay be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C- terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.Cellular_LocationMembrane; Single-pass type I membrane protein. Nucleus. Cytoplasm. Note=In cells that have undergone neuronal differentiation, the C-terminal cleaved part is translocated from the cytoplasm to the nucleus.Tissue_LocationObserved in all the tissues examined.