产品概述:This gene encodes a member of the GP40 family of Gprotein-coupled receptors that are clustered together on chromosome19. The encoded protein is a receptor for medium and long chainfree fatty acids and may be involved in the metabolic regulation ofinsulin secretion. Polymorphisms in this gene may be associatedwith type 2 diabetes.
靶点/蛋白:This FFAR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 275-300 amino acids from the C-terminal region of human FFAR1.
来源:Rabbit
存储溶液:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
参考文献:Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Lu, S.Y., et al. J. Mol. Graph. Model. 28(8):766-774(2010)Del Guerra, S., et al. Nutr Metab Cardiovasc Dis 20(1):22-25(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Nagasumi, K., et al. Diabetes 58(5):1067-1076(2009)
简单描述:Rabbit Polyclonal FFAR1 Antibody (C-term). Validated for use in WB, E.
详情:FunctionG-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose- stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway.Cellular_LocationCell membrane; Multi-pass membrane proteinTissue_LocationDetected in brain and pancreas. Detected in pancreatic beta cells.