产品概述:The FYVE domain mediates the recruitment of proteinsinvolved in membrane trafficking and cell signaling tophosphatidylinositol 3-phosphate (PtdIns(3)P)-containing membranes.This gene encodes a protein which contains two zinc-binding FYVEdomains in tandem. This protein displays a predominantly Golgi,endoplasmic reticulum and vesicular distribution. Alternativelyspliced transcript variants have been found for this gene, and theyencode two isoforms with different sizes.
靶点/蛋白:This ZFYVE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 145-173 amino acids from the N-terminal region of human ZFYVE1.
来源:Rabbit
存储溶液:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
参考文献:Wan, D., et al. Proc. Natl. Acad. Sci. U.S.A. 101(44):15724-15729(2004)Heilig, R., et al. Nature 421(6923):601-607(2003)Krugmann, S., et al. Mol. Cell 9(1):95-108(2002)Ridley, S.H., et al. J. Cell. Sci. 114 (PT 22), 3991-4000 (2001) :Cheung, P.C., et al. Biochem. J. 355 (PT 1), 113-121 (2001) :
特异性:Human
别名:Zinc finger FYVE domain-containing protein 1, Double FYVE-containing protein 1, SR3, Tandem FYVE fingers-1, ZFYVE1, DFCP1, KIAA1589, TAFF1, ZNFN2A1
应用:WB~~1:1000
简单描述:Rabbit Polyclonal ZFYVE1 Antibody (N-term). Validated for use in WB, E.
详情:Cellular_LocationGolgi apparatus, Golgi stack. Endoplasmic reticulum. Note=Resides predominantly in the cisternal stacks of the Golgi. Colocalizes with TRIM13 on the perinuclear endoplasmic reticulumTissue_LocationIsoform 1 is expressed in all tissues examined, including, brain, placenta, lung, liver, skeletal muscle, pancreas and kidney. Isoform 1 and isoform 2 are highly expressed in heart. Isoform 2 is also detected in the testis