产品概述:Synaptobrevins/VAMPs, syntaxins, and the 25-kDsynaptosomal-associated protein SNAP25 are the main components of aprotein complex involved in the docking and/or fusion of synapticvesicles with the presynaptic membrane. The protein encoded by thisgene is a member of the vesicle-associated membrane protein(VAMP)/synaptobrevin family. This protein may play a role intrans-Golgi network-to-endosome transport.
靶点/蛋白:This VAMP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 61-90 amino acids from the Central region of human VAMP4.
来源:Rabbit
存储溶液:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
参考文献:Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)Sabra, M.M., et al. Mol. Genet. Metab. 85(2):133-139(2005)Ballif, B.A., et al. Mol. Cell Proteomics 3(11):1093-1101(2004)Hinners, I., et al. EMBO Rep. 4(12):1182-1189(2003)
特异性:Human
别名:Vesicle-associated membrane protein 4, VAMP-4, VAMP4
应用:WB~~1:1000
简单描述:Rabbit Polyclonal VAMP4 Antibody (Center). Validated for use in WB, E.
详情:FunctionInvolved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule.Cellular_LocationGolgi apparatus, trans-Golgi network membrane; Single-pass type IV membrane protein. Note=Associated with trans Golgi network (TGN) and newly formed immature secretory granules (ISG). Not found on the mature secretory organelles