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- 2026年03月02日
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- 保存条件：
存储在2 - 8°C 2周，长期存储-20°C,防止冻融循环。
- 英文名：
Thyrotropin-Releasing Hormone Receptor 1 Antibody
- 供应商：
安诺伦（北京）生物科技有限公司
- 规格：
50 μl
产品概述：Thyrotropin-releasing hormone (TRH), is a widely distributed tripeptide which acts as a hormone, a paracrine regulatory factor and a neurotransmitter/neuromodulator; it is expressed in many parts of the brain as well as in various peripheral tissues1,2.In the hypothalamus, TRH is secreted from the paraventricular nucleus (VPN) by TRH neurons prior to a post-translational processing from its precursor, pro-TRH. A key player in the regulation of the hypothalamus-pituitary-thyroid (HPT) axis, TRH is released into the hypophyseal portal circulation of the median eminence and reaches the pituitary, where it binds to TRH receptors, thereby stimulates the secretion of tyrothropin (thyroid-stimulating hormone; TSH). TSH, in turn, affects the thyroid to produce T4 which is subsequently converted into its biologically-active analog, T3 - a negative mediator of TRH. In the tanycytes, ependymal cells of glial origin located in close proximity to the VPN, T4 is converted to T3 by the enzyme deiodinase II (dio2) - a counterpart to deiodinase III (dio3) which conversely inactivates the above mentioned thyroid hormones, thus so indirectly promotes the production of TRHs3,4.TRH receptor 1 (TRH-R1), the only identified TRH receptor in humans, is a G protein-coupled receptor (GPCR) abundant in the anterior pituitary, neuroendocrine system, autonomic nervous system and the visceral regions of the brain2,5. Like all members of GPCRs, TRH receptor has seven transmembrane domains, and extracellular N-terminus and an intracellular C-terminal tail. TRH receptor couples Gq upon activation which in turn leads to the activation of phospholipase C5.From a behavioral aspect, it was shown that TRH-coupled TRH-R1 increases cognitive arousal by directly exciting the sleep/wake system in the lateral hypothalamic area, and inhibits seizure activity in the hippocampus by facilitating GABA release, whereas its deficiency, as observed in mutant model mice, is linked to growth retardation, depression, and anxiety-like behavior1,6,7.Abgent is pleased to offer a highly specific antibody directed against an extracellular epitope of rat TRH-R. Anti-Thyrotropin-Releasing Hormone Receptor 1 antibody (#AG1004) can be used in western blot analysis. It has been designed to recognize TRH-R from rat, mouse and human samples.
靶点/蛋白：Peptide CKQKPTEKAANYS, corresponding to amino acid residues 337-349 of rat Thyrotropin-releasing hormone receptor 1 (Accession Q01717). Intracellular, C-terminus.
来源：Rabbit
存储溶液：Affinity purified antibody, lyophilized powder
参考文献：References1. Zeng, H. et al. (2007) Mol. Endocrinol. 21, 2795.2. Sun, Y. et al. (2003) J. Mol. Endocrinol. 30, 87.3. Costa-e-Sousa, R.H. et al. (2012) Endocrinology 153, 4128.4. Chiamolera, M.I. and Wondisford, F.E. et al. (2009) Endocrinology 150, 1091.5. Engel, S. and Gershengorn, M.C. (2007) Pharmacol. Ther. 113, 410.6. Hara, J. et al. (2009) J. Neurosci. 29, 3705.7. Deng, P.Y. et al. (2006) J. Physiol. 577, 497.
特异性：Human, Mouse, Rat
别名：Thyrotropin-releasing hormone receptor, TRH-R, Thyroliberin receptor, Trhr
应用：WB~~1:200-1:2000
简单描述：Rabbit Polyclonal Thyrotropin-Releasing Hormone Receptor 1 Antibody. Validated for use in WB.
生物商城：http://www.annoron.com
办公电话：010-56256916
官方售后：400-965-8633
企业 QQ：3212874516、3198592576
地 址：北京大兴经济技术开发区(亦庄)同济中路7号兴盛国际A栋4层
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文献和实验the dysfunction, which may result from defects in the gland; defects of releasing, trophic, or effector hormones; or defects of the target tissue. Hyperthyroidism, for example, may result from excessive thyrotropin-releasing hormone (TSH), or thyroid hormones
response. T and B lymphocytes have specific receptors that respond to specific antigen molecular shapes, called epitopes. In B cells, this receptor is an immunoglobulin, also called an antibody.
brain volume. Regardless of the type of cerebral edema, blood vessels become distorted and brain tissue is displaced, ultimately leading to herniation. Pain Pain is the result of a complex series of steps
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