产品概述:The protein encoded by this gene is a zinc fingertranscription factor that binds to RAS-responsive elements (RREs)of gene promoters. It has been shown that the calcitonin genepromoter contains an RRE and that the encoded protein binds thereand increases expression of calcitonin, which may be involved inRas/Raf-mediated cell differentiation. Multiple transcript variantsencoding several different isoforms have been found for this gene.
靶点/蛋白:This RREB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1398-1424 amino acids from the C-terminal region of human RREB1.
来源:Rabbit
存储溶液:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
参考文献:Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Neale, B.M., et al. Proc. Natl. Acad. Sci. U.S.A. 107(16):7395-7400(2010)Milon, B.C., et al. Prostate 70(3):288-296(2010)Flajollet, S., et al. J. Immunol. 183(11):6948-6959(2009)Liu, H., et al. Biochem. J. 422(3):543-551(2009)
特异性:Human
别名:Ras-responsive element-binding protein 1, RREB-1, Finger protein in nuclear bodies, Raf-responsive zinc finger protein LZ321, Zinc finger motif enhancer-binding protein 1, Zep-1, RREB1, FINB
应用:WB~~1:1000
简单描述:Rabbit Polyclonal RREB1 Antibody (C-term). Validated for use in WB, E.
详情:FunctionTranscription factor that binds specifically to the RAS- responsive elements (RRE) of gene promoters. May be involved in Ras/Raf-mediated cell differentiation by enhancing calcitonin expression. Represses the angiotensinogen gene. Negatively regulates the transcriptional activity of AR. Potentiates the transcriptional activity of NEUROD1.Cellular_LocationNucleus speckleTissue_LocationExpressed in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. Not found in the brain