产品概述:RAB11FIP2 is an adapter protein that plays a role in the secretory pathway. It is thought to be important for endosome recycling and receptor-mediated endocytosis. In endosome recycling, RAB11-FIP2 regulates vesicle transport from the endosomal recycling compartment (ERC) to the plasma membrane.
靶点/蛋白:This RAB11FIP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 345-374 amino acids from the Central region of human RAB11FIP2.
来源:Rabbit
存储溶液:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
参考文献:Wang, Z., et al. Cell 135(3):535-548(2008)Utley, T.J., et al. Proc. Natl. Acad. Sci. U.S.A. 105(29):10209-10214(2008)Ducharme, N.A., et al. Am. J. Physiol., Cell Physiol. 293 (3), C1059-C1072 (2007)
特异性:Human
别名:Rab11 family-interacting protein 2, Rab11-FIP2, NRip11, RAB11FIP2, KIAA0941
应用:WB~~1:1000IHC-P~~1:50~100FC~~1:10~50
简单描述:Rabbit Polyclonal RAB11FIP2 Antibody (Center). Validated for use in WB, IHC-P, FC, E.
详情:FunctionA Rab11 effector binding preferentially phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and phosphatidic acid (PA) and acting in the regulation of the transport of vesicles from the endosomal recycling compartment (ERC) to the plasma membrane. Involved in insulin granule exocytosis. Also involved in receptor-mediated endocytosis and membrane trafficking of recycling endosomes, probably originating from clathrin-coated vesicles. Required in a complex with MYO5B and RAB11 for the transport of NPC1L1 to the plasma membrane. Also acts as a regulator of cell polarity.Cellular_LocationCell membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein Note=Translocates with RAB11A from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane