产品概述:The protein kinase domain is predicted to be catalytically inactive. Molecular function: protein binding. There are two isoforms.
靶点/蛋白:This Mouse Mlkl antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 444-472 amino acids from the C-terminal region of mouse Mlkl.
来源:Rabbit
参考文献:Bisson, N., et al. Cell Cycle 7(7):909-916(2008)
简单描述:Rabbit Polyclonal Mlkl Antibody (C-term). Validated for use in WB.
详情:FunctionPseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.Cellular_LocationCytoplasm. Cell membrane. Note=Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction.Tissue_LocationHighly expressed in thymus, colon, intestine, liver, spleen and lung. Expressed at much lower level in skeletal muscle, heart and kidney. Not detected in brain