产品概述:Ectodysplasin A (EDA1) is a member of the TNF-related ligand family involved in the early epithelial-mesenchymal interaction that regulates ectodermal appendage formation (1). It is a trimeric type II membrane protein that co-localizes with cytoskeletal structures at the lateral and apical surfaces of cells and can be expressed as eight alternatively spliced isoforms in hair follicles and in the epidermis of adult skin (2,3). EDAs are required during development, and loss or mutation of EDA1 results in a group of developmental disorders identified as ectodermal dysplasia type 1 (4,5).
靶点/蛋白:EDA; EDA1 antibody is human, mouse and rat reactive. Multiple isoforms of EDA1 are known to exist.
来源:Rabbit
参考文献:Kere J, Srivastava AK, Montonen O. X-linked anhidrotic (hypohidrotic) ectodermal dysplasia is caused by mutation in a novel transmembrane protein. Nat. Genet. 1996; 13:409-16.Vincent MC, Biancalana V, Ginisty D, et al. Mutational spectrum of the ED1 gene in X-linked hypohidrotic ectodermal dysplasia. Eur. J. Hum. Genet. 2001; 9:355-63.Ohashi M, Moriya C, Tanahashi K, et al. A new EDA gene mutation in a family of X-linked hypohidrotic ectodermal dysplasia. J. Dermatol. Sci. 2014; 74:175-7.Bayés M, Hartung AJ, Ezer S, et al. The anhidrotic ectodermal dysplasia gene (EDA) undergoes alternative splicing and encodes ectodysplasin-A with deletion mutations in collagenous repeats. Hum. Mol. Genet. 1998; 7:1661-9.
特异性:Human, Mouse, Rat
简单描述:Rabbit Polyclonal EDA1 Antibody. Validated for use in WB, IHC-P, IF, E.
详情:FunctionSeems to be involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Isoform 1 binds only to the receptor EDAR, while isoform 3 binds exclusively to the receptor XEDAR.Cellular_LocationCell membrane; Single-pass type II membrane proteinTissue_LocationNot abundant; expressed in specific cell types of ectodermal (but not mesodermal) origin of keratinocytes, hair follicles, sweat glands. Also in adult heart, liver, muscle, pancreas, prostate, fetal liver, uterus, small intestine and umbilical chord. {ECO:0000269|Ref.6}