产品概述:This gene encodes a member of the WD repeat proteinfamily. WD repeats are minimally conserved regions of approximately40 amino acids typically bracketed by gly-his and trp-asp (GH-WD),which may facilitate formation of heterotrimeric or multiproteincomplexes. Members of this family are involved in a variety ofcellular processes, including cell cycle progression, signaltransduction, apoptosis, and gene regulation. This protein contains5 WD repeats, and has a structural similarity with actin-bindingproteins: the D. discoideum coronin and the human p57 protein,suggesting that this protein may also be an actin-binding proteinthat regulates cell motility. Alternative splicing of this genegenerates 2 transcript variants.
靶点/蛋白:This CORO2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 185-213 amino acids from the Central region of human CORO2A.
来源:Rabbit
存储溶液:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
参考文献:Jin, Y., et al. Nat. Genet. 42(7):576-578(2010)Marshall, T.W., et al. J. Cell. Sci. 122 (PT 17), 3061-3069 (2009) :Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)Yoon, H.G., et al. Mol. Cell 12(3):723-734(2003)Yoon, H.G., et al. EMBO J. 22(6):1336-1346(2003)
特异性:Human
别名:Coronin-2A, IR10, WD repeat-containing protein 2, CORO2A, IR10, WDR2
应用:WB~~1:1000
简单描述:Rabbit Polyclonal CORO2A Antibody (Center). Validated for use in WB, E.