产品概述:May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria- infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.
靶点/蛋白:Human CORO1A / p57
来源:Rabbit
参考文献:Suzuki K.,et al.FEBS Lett. 364:283-288(1995).Grogan A.,et al.Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases.Liau G.,et al.Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases.Kohchi C.,et al.Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.Ota T.,et al.Nat. Genet. 36:40-45(2004).
特异性:Human, Rat
别名:CORO1A, Clipin-A, Coronin-like protein A, Coronin-like protein p57, CLIPINA, Coronin-1, Coronin-1A, HCORO1, p57, TACO, CLABP, CORO1
应用:ICC (1:5000), IF (1:500 - 1:1000), IHC-P (1:100), WB (1:20000),
简单描述:Rabbit Polyclonal CORO1A / Coronin 1a Antibody. Validated for use in WB, IHC-P, IF, ICC.
详情:FunctionMay be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria- infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.Cellular_LocationCytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cytoplasmic vesicle, phagosome membrane. Note=In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification (By similarity).Tissue_LocationExpressed in brain, thymus, spleen, bone marrow and lymph node. Low in lung and gut