产品概述:COMMD7 (COMM domain-containing protein 7) plays a role in the regulation NF-kappaB (1). It associates with the NF-kB complex and suppresses its transcriptional activity (2). COMMD7 contains 1 COMM domain and widely expressed with highest expression in lung (3). COMMD7 is a newly identified gene overexpressed in hepatocellular carcinoma (HCC) (4). COMMD7 is associated with tumor invasion and poor prognosis by NF-kappaB signaling pathway (4).
靶点/蛋白:COMMD7; COMMD7 antibody is human, mouse and rat reactive. Multiple transcript variants encoding different isoforms have been found for COMMD7.
来源:Rabbit
参考文献:Maine GN and Burstein E. COMMD proteins and the control of the NF kappa B pathway. Cell Cycle 2007; 6:672-6.Burstein E, Hoberg JE, Wilkinson AS, et al. COMMD proteins, a novel family of structural and functional homologs of MURR1. J. Biol. Chem. 2005; 280:22222-32.Narindrasorasak S, Kulkarni P, Deschamps P, et al. Characterization and copper binding properties of human COMMD1 (MURR1). Biochemistry 2007; 46:3116-28.Zheng L, Liang P, Li J, et al. ShRNA-targeted COMMD7 suppresses hepatocellular carcinoma growth. PLoS One 2012; 7:e45412.
特异性:Human, Mouse, Rat
简单描述:Rabbit Polyclonal COMMD7 Antibody. Validated for use in WB, IHC-P, IF, E.
详情:FunctionMay modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Associates with the NF-kappa-B complex and suppresses its transcriptional activity (PubMed:15799966).Cellular_LocationCytoplasmic vesicleTissue_LocationWidely expressed with highest expression in lung.