产品概述:COL5A1 encodes an alpha chain for one of the lowabundance fibrillar collagens. Fibrillar collagen molecules aretrimers that can be composed of one or more types of alpha chains.Type V collagen is found in tissues containing type I collagen andappears to regulate the assembly of heterotypic fibers composed ofboth type I and type V collagen. COL5A1 product is closelyrelated to type XI collagen and it is possible that the collagenchains of types V and XI constitute a single collagen type withtissue-specific chain combinations. Mutations in this gene areassociated with Ehlers-Danlos syndrome, types I and II. [providedby RefSeq].
靶点/蛋白:This COL5A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 54-82 amino acids from the N-terminal region of human COL5A1.
来源:Rabbit
存储溶液:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
参考文献:Vitart, V., et al. Hum. Mol. Genet. 19(21):4304-4311(2010)Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Posthumus, M., et al. Med Sci Sports Exerc (2010) In press :Borck, G., et al. Am. J. Med. Genet. A 152A (8), 2090-2093 (2010) :
特异性:Human, Mouse
别名:Collagen alpha-1(V) chain, COL5A1
应用:WB~~1:1000IHC-P~~1:10~50
简单描述:Rabbit Polyclonal COL5A1 Antibody (N-term). Validated for use in WB, IHC-P, E.
详情:FunctionType V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin.Cellular_LocationSecreted, extracellular space, extracellular matrix {ECO:0000255|PROSITE-ProRule:PRU00793}