产品概述:CCRK contains a kinase domain most closely related to the cyclin-dependent protein kinases. This protein is involved in cell growth and activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue Thr-160.
靶点/蛋白:This CCRK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-45 amino acids from the N-terminal region of human CCRK.
来源:Rabbit
存储溶液:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
参考文献:Fujii, H., et al., Biochem. Biophys. Res. Commun. 322(3):1052-1058 (2004).Liu, Y., et al., J. Biol. Chem. 279(6):4507-4514 (2004).
简单描述:Rabbit Polyclonal CCRK Antibody (N-term). Validated for use in WB, E.
详情:FunctionRequired for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity). Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'.Cellular_LocationNucleus. Cytoplasm. Cell projection, cilium