产品概述:Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3 (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
靶点/蛋白:This CALCRL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 340-367 amino acids from the Central region of human CALCRL.
来源:Rabbit
存储溶液:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
参考文献:Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Kuwasako, K., et al. Biochem. Biophys. Res. Commun. 392(3):380-385(2010)Chang, C.L., et al. J. Biol. Chem. 285(2):1075-1080(2010)Barwell, J., et al. Peptides 31(1):170-176(2010)Yokoyama, K., et al. Nephron Clin Pract 115 (4), C237-C243 (2010) :
特异性:Human
别名:Calcitonin gene-related peptide type 1 receptor, CGRP type 1 receptor, Calcitonin receptor-like receptor, CALCRL, CGRPR
应用:WB~~1:1000
简单描述:Rabbit Polyclonal CALCRL Antibody (Center). Validated for use in WB, E.
详情:FunctionReceptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP3 (By similarity). Receptor for adrenomedullin together with RAMP2. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.Cellular_LocationCell membrane; Multi-pass membrane protein.Tissue_LocationPredominantly expressed in the lung and heart.