产品概述:This antibody is expected to recognize isoform 1 (NP_061496.2), 4 (NP_938199.1), 5 (NP_938194.1), 8 (NP_938198.1), 9 (NP_938192.1), 10 (NP_938200.1) and isoform 15 (NP_938407.1).
来源:Goat
存储溶液:0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
参考文献:Genetic enhancement of thalamocortical network activity by elevating alpha 1g-mediated low-voltage-activated calcium current induces pure absence epilepsy. Ernst WL, Zhang Y, Yoo JW, Ernst SJ, Noebels JL, J Neurosci. 2009 Feb 11;29(6):1615-25. PMID: 19211869
简单描述:Goat Polyclonal CACNA1G Antibody (internal region). Validated for use in E.
详情:FunctionVoltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channel is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.Cellular_LocationMembrane; Multi-pass membrane protein.Tissue_LocationHighly expressed in brain, in particular in the amygdala, subthalamic nuclei, cerebellum and thalamus Moderate expression in heart; low expression in placenta, kidney and lung. Also expressed in colon and bone marrow and in tumoral cells to a lesser extent. Highly expressed in fetal brain, but also in peripheral fetal tissues as heart, kidney and lung, suggesting a developmentally regulated expression