产品概述:Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi networkl (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN.
靶点/蛋白:Human C11orf2 / Fat-Free. At least two alternatively spliced isoforms are known to exist; this antibody will detect both isoforms.
别名:Vacuolar protein sorting-associated protein 51 homolog, Another new gene 2 protein, Protein fat-free homolog, VPS51, ANG2, C11orf2, C11orf3, FFR
应用:IHC-P (5 μg/ml), WB (1-2 μg/ml),
简单描述:Rabbit Polyclonal C11orf2 / Fat-Free Antibody (C-Terminus). Validated for use in WB, IHC-P.
详情:FunctionActs as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi networkl (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN.Cellular_LocationGolgi apparatus, trans-Golgi network