产品概述:The protein encoded by this gene is the medium subunit ofAP-3, which is an adaptor-related protein complex associated withthe Golgi region as well as more peripheral intracellularstructures. AP-3 facilitates the budding of vesicles from the Golgimembrane and may be directly involved in protein sorting to theendosomal/lysosomal system. AP-3 is a heterotetrameric proteincomplex composed of two large subunits (delta and beta3), a mediumsubunit (mu3), and a small subunit (sigma 3). Mutations in one ofthe large subunits of AP-3 have been associated with theHermansky-Pudlak syndrome, a genetic disorder characterized bydefective lysosome-related organelles. Alternatively splicedtranscript variants encoding the same protein have been observed.
靶点/蛋白:This AP3M1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 390-418 amino acids from the C-terminal region of human AP3M1.
来源:Rabbit
存储溶液:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
参考文献:Hashimoto, R., et al. Neurosci. Res. 65(1):113-115(2009)Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)Madrid, R., et al. EMBO J. 20(24):7008-7021(2001)Drake, M.T., et al. Mol. Biol. Cell 11(11):3723-3736(2000)Dell'Angelica, E.C., et al. Mol. Cell 3(1):11-21(1999)
简单描述:Rabbit Polyclonal AP3M1 Antibody (C-term). Validated for use in WB, E.
详情:FunctionPart of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.Cellular_LocationGolgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.