产品概述:COPII-coated vesicles are involved in protein transportfrom the endoplasmic reticulum to the Golgi apparatus. The proteinencoded by this gene was identified by its interaction with a mouseprotein similar to yeast Sec23p, an essential component of theCOPII. This protein shares significant similarity withphospholipid-modifying proteins, especially phosphatidic acidpreferring-phospholipase A1. Overexpression of this protein hasbeen shown to cause disorganization of the endoplasmicreticulum-Golgi intermediate compartment and Golgi apparatus, whichsuggests its role in the early secretory pathway. [provided byRefSeq].
靶点/蛋白:This SEC23IP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 724-752 amino acids from the C-terminal region of human SEC23IP.
来源:Rabbit
存储溶液:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
参考文献:Ong, Y.S., et al. J. Cell Biol. 190(3):331-345(2010)Trynka, G., et al. Gut 58(8):1078-1083(2009)Li, H., et al. J. Biol. Chem. 281(21):14748-14755(2006)Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)Shimoi, W., et al. J. Biol. Chem. 280(11):10141-10148(2005)
特异性:Human
别名:SEC23-interacting protein, p125, SEC23IP
应用:WB~~1:1000
简单描述:Rabbit Polyclonal SEC23IP Antibody (C-term). Validated for use in WB, E.
详情:FunctionPlays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI(3)P), phosphatidylinositol 4-phosphate (PI(4)P) and phosphatidylinositol 5-phosphate (PI(5)P).Cellular_LocationCytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side Endoplasmic reticulumTissue_LocationUbiquitously expressed with stronger levels detected in heart, liver and skeletal muscle