产品概述:Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).
靶点/蛋白:This RON antibody is generated from rabbits immunized with two KLH conjugated synthetic peptides between 22-51 amino and 1370-1400 acids from the N-terminal and C-terminal regions of human RON.
来源:Rabbit
存储溶液:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
参考文献:Maggiora, P., et al., Exp. Cell Res. 288(2):382-389 (2003).Santoro, M.M., et al., Dev. Cell 5(2):257-271 (2003).Penengo, L., et al., Oncogene 22(24):3669-3679 (2003).Zhou, Y.Q., et al., Oncogene 22(2):186-197 (2003).Danilkovitch-Miagkova, A., et al., Proc. Natl. Acad. Sci. U.S.A. 100(8):4580-4585 (2003).
特异性:Human
别名:Macrophage-stimulating protein receptor, MSP receptor, CDw136, Protein-tyrosine kinase 8, p185-Ron, CD136, Macrophage-stimulating protein receptor alpha chain, Macrophage-stimulating protein receptor beta chain, MST1R, PTK8, RON
应用:WB~~1:1000
简单描述:Rabbit Polyclonal RON Antibody. Validated for use in WB, E.
详情:FunctionReceptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.Cellular_LocationMembrane; Single-pass type I membrane proteinTissue_LocationExpressed in colon, skin, lung and bone marrow.