产品概述:Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.
靶点/蛋白:Detect an ~32kD protein, corresponding to the molecular mass of HO-1 on SDS Page Western Blots.
简单描述:Rabbit Polyclonal HMOX1 / HO-1 Antibody. Validated for use in WB, IHC-P.
详情:FunctionHeme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.Cellular_LocationMicrosome. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic sideTissue_LocationExpressed at higher levels in renal cancer tissue than in normal tissue (at protein level)