产品概述:The product of this gene belongs to the FGGY kinase familyof proteins and encodes glycerol kinase. Glycerol kinase is a keyenzyme in the regulation of glycerol uptake and metabolism. Itcatalyzes the phosphorylation of glycerol by ATP, yielding ADP andglycerol-3-phosphate. Defects in this gene are the cause ofglycerol kinase deficiency (GKD). Alternatively spliced transcriptvariants encoding different isoforms have been identified.
靶点/蛋白:This GK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-51 amino acids from the N-terminal region of human GK.
来源:Rabbit
存储溶液:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
参考文献:Lu, Y., et al. J. Lipid Res. 49(12):2582-2589(2008)Zhang, Y.H., et al. Pediatr. Res. 59 (4 PT 1), 590-592 (2006) :Ohira, R.H., et al. Biochem. Biophys. Res. Commun. 331(1):239-246(2005)Stepanian, S.V., et al. Mol. Genet. Metab. 80(4):412-418(2003)Hellerud, C., et al. Clin. Chem. Lab. Med. 41(1):46-55(2003)
简单描述:Rabbit Polyclonal GK Antibody (N-term). Validated for use in WB, IHC-P, E.
详情:FunctionKey enzyme in the regulation of glycerol uptake and metabolism.Cellular_LocationMitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Note=In sperm and fetal tissues, the majority of the enzyme is bound to mitochondria, but in adult tissues, such as liver found in the cytoplasmTissue_LocationHighly expressed in the liver, kidney and testis. Isoform 2 and isoform 3 are expressed specifically in testis and fetal liver, but not in the adult liver