产品概述:This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants.
来源:Goat
存储溶液:0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
参考文献:Association of CYP19 and ESR1 Pleiotropic Genes With Human Longevity. Corbo RM, et al. J Gerontol A Biol Sci Med Sci, 2010 Sep 5. PMID 20819792.Epistasis between CYP19A1 and ESR1 polymorphisms is associated with premature ovarian failure. Kim S, et al. Fertil Steril, 2010 Aug 24. PMID 20797716.Association of CYP19A1 polymorphisms with risks for atypical adenomatous hyperplasia and bronchioloalveolar carcinoma in the lungs. Kohno T, et al. Carcinogenesis, 2010 Aug 5. PMID 20688833.Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium. Canzian F, et al. Hum Mol Genet, 2010 Oct 1. PMID 20634197.Genetic susceptibility to urinary incontinence: implication of polymorphisms of androgen and oestrogen pathways. Cornu JN, et al. World J Urol, 2010 Jul 14. PMID 20628746.
简单描述:Goat Polyclonal Goat Anti-Aromatase / CYP19A1 Antibody. Validated for use in WB, E.
详情:FunctionCatalyzes the formation of aromatic C18 estrogens from C19 androgens.Cellular_LocationMembrane; Peripheral membrane protein.Tissue_LocationBrain, placenta and gonads.