产品概述:Cytochrome c oxidase (COX), the terminal enzyme of themitochondrial respiratory chain, catalyzes the electron transferfrom reduced cytochrome c to oxygen. It is a heteromeric complexconsisting of 3 catalytic subunits encoded by mitochondrial genesand multiple structural subunits encoded by nuclear genes. Themitochondrially-encoded subunits function in electron transfer, andthe nuclear-encoded subunits may be involved in the regulation andassembly of the complex. This nuclear gene encodes subunit VIb.Mutations in this gene are associated with severe infantileencephalomyopathy. Three pseudogenes COX6BP-1, COX6BP-2 andCOX6BP-3 have been found on chromosomes 7, 17 and 22q13.1-13.2,respectively.
靶点/蛋白:This COX6B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 59-86 amino acids from the C-terminal region of human COX6B1.
来源:Rabbit
存储溶液:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
参考文献:Lazarou, M., et al. FEBS J. 276(22):6701-6713(2009)Massa, V., et al. Am. J. Hum. Genet. 82(6):1281-1289(2008)Sirchia, R., et al. Biol. Chem. 388(5):457-465(2007)Schmidt, T.R., et al. Gene 286(1):13-19(2002)Taanman, J.W., et al. Hum. Genet. 87(3):325-327(1991)
特异性:Human
别名:Cytochrome c oxidase subunit 6B1, Cytochrome c oxidase subunit VIb isoform 1, COX VIb-1, COX6B1, COX6B
应用:WB~~1:1000IHC-P~~1:10~50
简单描述:Rabbit Polyclonal COX6B1 Antibody (C-term). Validated for use in WB, IHC-P, E.
详情:FunctionConnects the two COX monomers into the physiological dimeric form.Cellular_LocationMitochondrion intermembrane space