产品概述:This antibody is expected to recognize both isoforms (NP_113659.3, NP_848537.1).
来源:Goat
存储溶液:0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
参考文献:Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation. Svensson L, Howarth K, McDowall A, Patzak I, Evans R, Ussar S, Moser M, Metin A, Fried M, Tomlinson I, Hogg N. Nature medicine 2009 Mar 15 (3): 306-12. PMID: 19234463
特异性:Human
别名:Fermitin family homolog 3, Kindlin-3, MIG2-like protein, Unc-112-related protein 2, FERMT3, KIND3, MIG2B, URP2
简单描述:Goat Polyclonal URP2 / kindlin-3 Antibody (C-Term). Validated for use in WB, E.
详情:FunctionPlays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity).Cellular_LocationCell projection, podosome. Note=Present in the F-actin surrounding ring structure of podosomes, which are specialized adhesion structures of hematopoietic cells.Tissue_LocationHighly expressed in lymph node. Expressed in thymus, spleen and leukocytes. Weakly expressed in placenta, small intestine, stomach, testis and lung. Overexpressed in B-cell malignancies.