产品概述:Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells.
来源:Goat
存储溶液:0.5 mg IgG/ml in Tris saline (20mM Tris pH7.3, 150mM NaCl), 0.02% sodium azide, with 0.5% bovine serum albumin
参考文献:Genome-wide searching of rare genetic variants in WTCCC data. Feng T, et al. Hum Genet, 2010 Sep. PMID 20549515.Incorporation of podoplanin into HIV released from HEK-293T cells, but not PBMC, is required for efficient binding to the attachment factor CLEC-2. Chaipan C, et al. Retrovirology, 2010 May 19. PMID 20482880.New genetic associations detected in a host response study to hepatitis B vaccine. Davila S, et al. Genes Immun, 2010 Apr. PMID 20237496.CLEC-2 activates Syk through dimerization. Hughes CE, et al. Blood, 2010 Apr 8. PMID 20154219.Phosphorylation of CLEC-2 is dependent on lipid rafts, actin polymerization, secondary mediators, and Rac. Pollitt AY, et al. Blood, 2010 Apr 8. PMID 20154214.
特异性:Human
别名:C-type lectin domain family 1 member B, C-type lectin-like receptor 2, CLEC-2, CLEC1B, CLEC2
简单描述:Goat Polyclonal Goat Anti-CLEC2 / CLEC1B Antibody. Validated for use in WB, E.
详情:Cellular_LocationMembrane; Single-pass type II membrane proteinTissue_LocationExpressed preferentially in the liver. Also expressed in immune cells of myeloid origin and on the surface of platelets.