产品概述:The protein encoded by this gene is a member of theETS-domain transcription factor family and the ternary complexfactor (TCF) subfamily. Proteins in this subfamily regulatetranscription when recruited by serum response factor to bind toserum response elements. This protein is activated bysignal-induced phosphorylation; studies in rodents suggest that itis a transcriptional inhibitor in the absence of Ras, but activatestranscription when Ras is present.
靶点/蛋白:This ELK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 98-126 amino acids from the N-terminal region of human ELK3.
来源:Rabbit
存储溶液:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
参考文献:Serchov, T., et al. J. Biol. Chem. 285(28):21223-21232(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Li, B., et al. Tohoku J. Exp. Med. 216(2):139-147(2008)Wasylyk, C., et al. Cancer Res. 68(5):1275-1283(2008)Wu, C., et al. Proteomics 7(11):1775-1785(2007)
特异性:Human
别名:ETS domain-containing protein Elk-3, ETS-related protein ERP, ETS-related protein NET, Serum response factor accessory protein 2, SAP-2, SRF accessory protein 2, ELK3, NET, SAP2
应用:WB~~1:1000
简单描述:Rabbit Polyclonal ELK3 Antibody (N-term). Validated for use in WB, E.
详情:FunctionMay be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.Cellular_LocationNucleus.