产品概述:This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade.
靶点/蛋白:Human CD55
来源:Rabbit
参考文献:Caras I.W.,et al.Nature 325:545-549(1987).Osuka F.,et al.Genomics 88:316-322(2006).Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.Gregory S.G.,et al.Nature 441:315-321(2006).Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
简单描述:Rabbit Polyclonal CD55 Antibody (aa71-330). Validated for use in WB, IHC-P, ICC.
详情:FunctionThis protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade.Cellular_LocationIsoform 1: Cell membrane; Single-pass type I membrane protein Isoform 3: Secreted Isoform 5: Secreted Isoform 7: Cell membrane; Lipid-anchor, GPI-anchorTissue_LocationExpressed on the plasma membranes of all cell types that are in intimate contact with plasma complement proteins. It is also found on the surfaces of epithelial cells lining extracellular compartments, and variants of the molecule are present in body fluids and in extracellular matrix