靶点/蛋白:Rabbit anti-RIG-I antibody recognizes human Retinoic acid-inducible gene 1 protein (RIG-I), also known as RIG-1 or DEAD-box protein 58. RIG-I is a receptor found in the cytoplasm that recognizes viral RNA from replicating viruses in infected cells. Upon activation with intracellular RNA, a cascade is triggered resulting in the activation of NF-kappa-B, and the eventual induction of antiviral cytokines such as IFN-beta and RANTES. RIG-I is essential for the production of interferons in response to RNA viruses and as such play a key role in innate immunity.
来源:Rabbit
参考文献:1. Satoh, T. et al. (2014) Tumor microenvironment and RIG-I signaling molecules in Epstein Barr virus-positive and -negative classical Hodgkin lymphoma of the elderly.J Clin Exp Hematop. 54: 75-84.1. Akira S, et al (2006) Pathogen recognition and innate immunity124:783-8012. Yoneyama M et al (2004) The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.Nat. Immunol.; 5:730-737.3. Sharma S, et al (2003) Triggering the interferon antiviral response through an IKK-related pathwayScience 300:1148-51.4. Alexopoulou L, et al (2001) Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3Nature 413:732-8
特异性:Human
别名:Probable ATP-dependent RNA helicase DDX58, 3.6.4.13, DEAD box protein 58, RIG-I-like receptor 1, RLR-1, Retinoic acid-inducible gene 1 protein, RIG-1, Retinoic acid-inducible gene I protein, RIG-I, DDX58
简单描述:Rabbit Polyclonal Anti-RIG-I Antibody . Validated for use in WB, IHC-P.