靶点/蛋白:Goat anti-Human MIP-1 alpha antibody recognizes human MIP-1 alpha, otherwise known as CCL3, a 69 amino acid member of the CC chemokine family which plays a critical role in haematopoiesis and is shown to signal through the chemokine receptors CCR1, CCR4 and CCR5.MIP-1 alpha is also involved in host defence against invading pathogens, acting as a regulator of activation and trafficking of inflammatory cells, such as macrophages, NK cells, granulocytes, dendritic cells and CD8+ lymphocytes. The recruitment of inflammatory cells by MIP-1 alpha, has been linked with the pathogenesis of several diseases, including rheumatoid arthritis, H. pylori associated gastritis and bacterial meningitis.The secretion of MIP-1 alpha by CD8+ lymphocytes acts as a major HIV-suppressive factor (HIV-SF) through binding to CCR5, identified as a coreceptor for HIV-1 target cell entry.
来源:Goat
参考文献:1. Cocchi, F. et al. (1996) Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. Science 274: 1393-1395.1. Menten, P. et al. (2002) Macrophage inflammatory protein-1. Cyt. Growth Factor 13: 455-481.