靶点/蛋白:ABD13317 specifically recognises PUM1 (pumilio-1), an evolutionarily conserved sequence-specific RNA-binding protein and member of the PUF family, which acts as a regulator of specific mRNA translation, through interaction with 3' untranslated regions (UTRs).The original member of the PUF family, pumilio of Drosophila melanogaster (DmPUM), was found to be important in the regulation of germ-line stem cell development and neuronal function, suggesting a similar role for vertebrate PUM proteins.