产品概述:CPZ is a member of the metallocarboxypeptidase family. This enzyme displays carboxypeptidase activity towards substrates with basic C-terminal residues. It is most active at neutral pH and is inhibited by active site-directed inhibitors of metallocarboxypeptidases.
靶点/蛋白:This CPZ antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 143-172 amino acids from the N-terminal region of human CPZ.
来源:Rabbit
存储溶液:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
参考文献:Fan,X., J. Histochem. Cytochem. 50 (11), 1509-1516 (2002)Reznik,S.E., Cell. Mol. Life Sci. 58 (12-13), 1790-1804 (2001)
特异性:Human
别名:Carboxypeptidase Z, CPZ, 3417-, CPZ
应用:WB~~1:1000IHC-P~~1:50~100
简单描述:Rabbit Polyclonal CPZ Antibody (N-term). Validated for use in WB, IHC-P, E.
详情:FunctionCleaves substrates with C-terminal arginine residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing.Cellular_LocationSecreted, extracellular space, extracellular matrixTissue_LocationIn placenta, it is present within invasive trophoblasts and in the surrounding extracellular space. Also present in amnion cells, but is not readily apparent in the extracellular matrix of this cell type. Present in normal pituitary gland and neoplastic pituitary gland (especially POMC-, GH- and PRL-producing adenomas) (at protein level). Widely expressed.