产品概述:The protein encoded by this gene belongs to the BCL-2protein family. BCL-2 family members form hetero- or homodimers andact as anti- and pro-apoptotic regulators that are involved in awide variety of cellular activities. This protein contains all fourBCL-2 like domains (BH1, 2, 3 and 4) and is a pro-apoptotic BCL-2protein identified in the ovary.
靶点/蛋白:This BOK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human BOK.
来源:Rabbit
存储溶液:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
参考文献:Stein, J.L., et al. Neuroimage 53(3):1160-1174(2010)Ray, J.E., et al. Cell Death Differ. 17(5):846-859(2010)Zhang, H., et al. Int. J. Oncol. 34(4):1135-1138(2009)Rodriguez, J.M., et al. J. Biol. Chem. 281(32):22729-22735(2006)Bartholomeusz, G., et al. Mol. Carcinog. 45(2):73-83(2006)
简单描述:Rabbit Polyclonal BOK Antibody (N-term). Validated for use in WB, E.
详情:FunctionInduces apoptosis in a manner dependent on BAX and BAK.Cellular_LocationEndoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein. Note=The transmembrane domain is necessary and sufficient for Golgi and ER targetingTissue_LocationExpressed in brain, liver, appendix and lymphoid tissues.