产品概述:This gene is regulated as part of the p53 tumor suppressorpathway and encodes a protein with sequence similarity to thebisphosphate domain of the glycolytic enzyme that degradesfructose-2,6-bisphosphate. The protein functions by blockingglycolysis and directing the pathway into the pentose phosphateshunt. Expression of this protein also protects cells from DNAdamaging reactive oxygen species and provides some protection fromDNA damage-induced apoptosis. The 12p13.32 region that includesthis gene is paralogous to the 11q13.3 region. [provided byRefSeq].
靶点/蛋白:This TIGAR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human TIGAR.
来源:Rabbit
存储溶液:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
参考文献:Bensaad, K., et al. EMBO J. 28(19):3015-3026(2009)Trevino, L.R., et al. Nat. Genet. 41(9):1001-1005(2009)Lopez-Guerra, M., et al. Haematologica 93(12):1843-1851(2008)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Bensaad, K., et al. Cell 126(1):107-120(2006)
特异性:Mouse
别名:Fructose-2, 6-bisphosphatase TIGAR, TP53-induced glycolysis and apoptosis regulator, TIGAR, C12orf5
应用:WB~~1:1000
简单描述:Rabbit Polyclonal TIGAR Antibody (N-term). Validated for use in WB, E.
详情:FunctionFructose-bisphosphatase hydrolyzing fructose-2,6- bisphosphate as well as fructose-1,6-bisphosphate. Inhibits glycolysis by reducing cellular levels of fructose-2,6- bisphosphate. May protect cells against reactive oxygen species and against apoptosis induced by tp53.