产品概述:The proteasome is a multicatalytic proteinase complex witha highly ordered ring-shaped 20S core structure. The core structureis composed of 4 rings of 28 non-identical subunits; 2 rings arecomposed of 7 alpha subunits and 2 rings are composed of 7 betasubunits. Proteasomes are distributed throughout eukaryotic cellsat a high concentration and cleave peptides in anATP/ubiquitin-dependent process in a non-lysosomal pathway. Anessential function of a modified proteasome, the immunoproteasome,is the processing of class I MHC peptides. This gene encodes amember of the peptidase T1A family, that is a 20S core alphasubunit. Alternative splicing results in multiple transcriptvariants encoding distinct isoforms.
靶点/蛋白:This PSMA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 234-262 amino acids from the C-terminal region of human PSMA1.
来源:Rabbit
存储溶液:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
参考文献:Zhang, Y., et al. Biochem. Biophys. Res. Commun. 355(1):245-251(2007)Apcher, G.S., et al. FEBS Lett. 569 (1-3), 211-216 (2004) :Jayarapu, K., et al. Biochem. Biophys. Res. Commun. 314(2):523-528(2004)Apcher, G.S., et al. FEBS Lett. 553 (1-2), 200-204 (2003) :Huang, X., et al. J. Mol. Biol. 323(4):771-782(2002)
简单描述:Rabbit Polyclonal PSMA1 Antibody (C-term). Validated for use in WB, E.
详情:FunctionThe proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. Mediates the lipopolysaccharide-induced signal transduction in the macrophage proteasome (By similarity). Might be involved in the anti-inflammatory response of macrophages during the interaction with C.albicans heat-inactivated cells (By similarity).Cellular_LocationCytoplasm. Nucleus.