存储溶液:0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
参考文献:A novel pleckstrin homology-related gene family defined by Ipl/Tssc3, TDAG51, and Tih1: tissue-specific expression, chromosomal location, and parental imprinting. Frank D, Mendelsohn CL, Ciccone E, Svensson K, Ohlsson R, Tycko B. Mamm Genome. 1999 Dec;10(12):1150-9. PMID: 10594239
特异性:Human
别名:Pleckstrin homology-like domain family A member 3, TDAG51/Ipl homolog 1, PHLDA3, TIH1
简单描述:Goat Polyclonal PHLDA3 / TIH1 Antibody (C-Term). Validated for use in WB, E.
详情:Functionp53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor.Cellular_LocationCytoplasm. Membrane; Peripheral membrane proteinTissue_LocationWidely expressed with lowest expression in liver and spleen.