产品概述:Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C- APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.
靶点/蛋白:NEDD8 Antibody detects endogenous levels of total NEDD8 protein.
简单描述:Rabbit Polyclonal NEDD8 Antibody (aa10-59). Validated for use in WB, IHC-P, E.
详情:FunctionUbiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C- APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.Cellular_LocationNucleus. Note=Mainly nuclearTissue_LocationHighly expressed in heart, skeletal muscle, spleen, thymus, prostate, testis, ovary, colon and leukocytes