产品概述:This gene encodes a member of the membrane-spanning 4Agene family. Members of this protein family are characterized bycommon structural features and similar intron/exon spliceboundaries and display unique expression patterns amonghematopoietic cells and nonlymphoid tissues. This family memberlikely plays a role in signal transduction and may function as asubunit associated with receptor complexes. The gene encoding thisprotein is localized to 11q12, among a cluster of related familymembers. Alternative splicing may result in multiple transcriptvariants; however, not all variants have been fully described.
靶点/蛋白:This MS4A3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 97-123 amino acids from the Central region of human MS4A3.
来源:Rabbit
存储溶液:Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
参考文献:Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Lamesch, P., et al. Genomics 89(3):307-315(2007)Chinami, M., et al. J. Biol. Chem. 280(17):17235-17242(2005)Donato, J.L., et al. J. Clin. Invest. 109(1):51-58(2002)
特异性:Human
别名:Membrane-spanning 4-domains subfamily A member 3, CD20 antigen-like protein, Hematopoietic-specific transmembrane protein 4, HTm4, MS4A3, CD20L, HTM4
应用:WB~~1:1000
简单描述:Rabbit Polyclonal MS4A3 Antibody (Center). Validated for use in WB, E.
详情:FunctionHematopoietic modulator for the G1-S cell cycle transition. Modulates the level of phosphorylation of cyclin- dependent kinase 2 (CDK2) through its direct binding to cyclin- dependent kinase inhibitor 3 (CDKN3/KAP).Cellular_LocationEndomembrane system; Multi- pass membrane protein. Cytoplasm, perinuclear region. Note=Located in the perinuclear areaTissue_LocationExpressed specifically in hematopoietic cells and tissues