存储溶液:Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
参考文献:Niikura T.,et al.Blood Cells Mol. Dis. 23:337-349(1997).Ota T.,et al.Nat. Genet. 36:40-45(2004).Ebert L.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.Deloukas P.,et al.Nature 429:375-381(2004).Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
特异性:Human, Bovine
别名:Interferon-induced protein with tetratricopeptide repeats 5, IFIT-5, Interferon-induced 58 kDa protein, Retinoic acid- and interferon-inducible 58 kDa protein, P58, IFIT5, ISG58, RI58
简单描述:Rabbit Polyclonal IFIT5 antibody - N-terminal region. Validated for use in WB.
详情:FunctionInterferon-induced RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP- RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Also recognizes and binds tRNAs.Cellular_LocationCell projection, ruffle membrane. Note=Colocalized with DDX58/RIG-I at cell surface ruffles. Localizes to actin-rich protrusions from the apical cell surface